Showing posts with label Bioinformatics Database. Show all posts
Showing posts with label Bioinformatics Database. Show all posts
Thursday, February 28, 2013 Tags: , , , , 0 comments

How to Use ADT (Auto Dock Tool) Docking Manual




Full Explanation of docking tool using ADT Auto Dock Tool.

Bioinformatics Database



1.Nucleotide Sequence Databases
1.1 International Nucleotide Sequence Database Collaboration
Database name
Full name and/or description
URL
DDBJ-DNA Data Bank of Japan
All known nucleotide and protein sequences
EMBL-Nucleotide Sequence Database
All known nucleotide and protein sequences
GenBank
All known nucleotide and protein sequences


1.2. DNA sequences: genes, motifs and regulatory sites



1.2.1. Coding and coding DNA


Database name
Full name and/or description
URL
ACLAME
A classification of genetic mobile elements
CUTG
Codon usage tabulated from GenBank
Genetic Codes
Genetic codes in various organisms and organelles
Entrez Gene
Gene-centered information at NCBI
HERVd
Human endogenous retrovirus database
Hoppsigen
Human and mouse homologous processed pseudogenes
Imprinted Gene Catalogue
Imprinted genes and parent-of-origin effects in animals
Islander
Pathogenicity islands and prophages in bacterial genomes
MICdb
Prokaryotic microsatellites
NPRD
Nucleosome positioning region database
STRBase
Short tandem DNA repeats database
TIGR Gene Indices
Organism-specific databases of EST and gene sequences
Transterm
Codon usage, start and stop signals
UniGene
Non-redundant set of eukaryotic gene-oriented clusters
UniVec
Vector sequences, adapters, linkers and primers used in DNA cloning, can be used to check for vector contamination
VectorDB
Characterization and classification of nucleic acid vectors
Xpro
Eukaryotic protein-encoding DNA sequences, both intron-containing and intron- less genes

1.2.2. Gene structure, introns and exons, splice sites


Database name
Full name and/or description
URL
ASAP
Alternative spliced isoforms
ASD
Alternative splicing database at EBI, includes three databases AltSplice, AltExtron and AEdb
ASDB
Alternative splicing database: protein products and expression patterns of alternatively spliced genes
ASHESdb
Alternatively spliced human genes by exon skipping database
EASED
Extended alternatively spliced EST database
ECgene
Genome annotation for alternative splicing
EDAS
EST-derived alternative splicing database
ExInt
Exon intron structure of eukaryotic genes
HS3D
Homo sapiens splice sites dataset
Intronerator
Alternative splicing in C.elegans and C.briggsae
SpliceDB
Canonical and non-canonical mammalian splice sites
SpliceInfo
Modes of alternative splicing in human genome
SpliceNest
A tool for visualizing splicing of genes from EST data

1.2.3. Transcriptional regulator sites and transcription factors

Sequence analysis

Sequence analysis is the application of Information Technologies to Molecular Biology. It deals with biological sequences, and processes them to extract significant information that may yield new insights and guidelines in the understanding of biological organisms
Basics for sequence analysis

Proteins

A protein is typically built of a series of basic blocks called amino acids , chained together in a linear sequence of blocks. Amino acids may come in a variety of shapes and properties: they may be small or bulky, hidrophobic or hidrophyllic, electrically charged or neutral, etc... hence allowing for very complex shapes and interactions to be produced.

Amino acids are commonly referred to by name or by an abbreviation, usually in three or one letter. This allows for more efficient descriptions of how they are chained together to build a protein:
Neutral-Nonpolar
3-letter
1-letter
Glycine
Gly
G
L-Alanine
Ala
A
L-Valine
Val
V
L-Isoleucine
Ile
I
L-Leucine
Leu
L
L-Phenylalanine
Phe
F
L-Proline
Pro
P
L-Methionine
Met
M
Neutral-Polar
 
 
L-Serine
Ser
S
L-Threonine
Thr
T
L-Tyrosine
Tyr
Y
L-Tryptophan
Trp
W
L-Asparagine
Asn
N
L-Glutamine
Gln
Q
L-Cysteine
Cys
C
Acidic
 
 
L-Aspartic
Asp
D
L-Glutamic
Glu
E
Basic
 
 
L-Lysine
Lys
K
L-Arginine
Arg
R
L-Histidine
His
H

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